The development of cascade conversions (catalytic reactions without intermediate isolation steps as performed in living cells) is considered as one of the important directions for performing sustainable organic synthesis. Here the biochemical apparatus has been evolved over billion of years to a perfectly designed network of catalytic reactions carried out by enzymes and small molecules (co-factors). Starting from simple molecules (i.e. H2, NH3, CO2, H20, O2) complex molecules are build up under cascade catalysis and the creation of life begins. It is an excellent inspiration point for the future design of eco-friendly chemistry, material science and engineering.